Complement system of Human body 2

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Let us see the mechanism of classical complementary pathway. 
 
CLASSICAL COMPLEMENTARY PATHWAY 
 
C1 protein (complementary protein 1) is always circulating in our blood stream in an inactivated form. Once foreign particle enters human body it becomes activated. 

Then C1 activates C4 protein and activated part of C4 binds to C1 abbreviated as C4b the inactivated part of C4 (C4a) is released.

Then C4b in the same manner activates C2 and activated form of C2 i.e. C2b binds to it and C2a is released 

Then the Complex C4b-C2b act as C3 convertase and activates C3 in to C3b

Then the complex C4b-C2b-C3b act as C5 convertase and activates C5 

Then C5 binds to C6 C7 C8 C9 and this chain C5-C9 is the main machinery responsible for making pores in cell membrane of foreign particle. 

Here we end classical pathway of complementary system.

Thank you for reading blog 




Comments

  1. Unknown2 June 2021 at 11:16

    Your topic is really interesting. I love this site. Carry on,don't stop!

    ReplyDelete
  2. Cook book2 June 2021 at 21:36

    Easy to understand ✨

    ReplyDelete

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